期刊
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
卷 79, 期 3, 页码 241-257出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.cmpb.2005.04.005
关键词
pharmacokinetics; pharmacodynamics; NONMEM; Bootstrap; Jackknife; Log-likelihood Profiling; Case-Deletion Diagnostics; Stepwise Covariate Model building; computer intensive methods; Perl
PsN-Toolkit is a collection of statistical tools for pharmacometric data analysis using the non-linear mixed effect modeling software NONMEM. The toolkit is object oriented and written in the programming language Pert using the programming Library Pert-speaks -NONMEM (PsN). Five methods: the Bootstrap, the Jackknife, Log-likelihood Profiling, Case-deletion Diagnostics and Stepwise Covariate Model building are included as separate classes and may be used in user-written Pert scripts or through stand-alone command line applications. The tools are designed with the ability to cooperate and with an emphasis on common structures for workflow and result handling. Parallel execution of independent tool sections is supported on shared memory multiprocessor (SMP) computers, Mosix/openMosix clusters and distributed computing environments following the NorduGrid standard. In conclusion, PsN-Toolkit makes it easier to use the Bootstrap, the Jackknife, Log-likelihood Profiling, Case-deletion Diagnostics and Stepwise Covariate Model building in pharmacometric data analysis. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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