期刊
NATURE IMMUNOLOGY
卷 6, 期 9, 页码 895-901出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni1240
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- NIAID NIH HHS [F32-AI054107, R01-AI40618] Funding Source: Medline
T cell circulation between peripheral tissues and the lymphoid compartment is critical for immunosurveillance and host defense. However, the factors that determine whether T cells remain in peripheral tissue or return to the circulation are undefined. Here we demonstrate that the chemokine receptor CCR7 is a critical signal that determines T cell exit from peripheral tissue. Both CCR7 (-) and CCR7(+) effector T cells entered mouse asthmatic lung and while CCR7 (-) T cells accumulated, CCR7(+) T cells continued to migrate into afferent lymph. Delivery of both CCR7(+) and CCR7(-) T cells directly into the airways showed that only CCR7(+) T cells exited the lung and entered draining lymph nodes. Our study establishes a molecular basis for T cell exit from peripheral tissues.
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