期刊
JOURNAL OF IMMUNOLOGY
卷 175, 期 5, 页码 3268-3272出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.175.5.3268
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- NHLBI NIH HHS [R01 HL645450] Funding Source: Medline
Although dendritic cells (DC) are potent APC that prime T cells against many pathogens, there is no direct evidence that DC are required for immunity to Mycobacterium tuberculosis (Mtb) infection. The requirement for DC to prime the CD4(+) T cell response following Mtb infection was investigated using pCD11c-diptheria toxin receptor/GFP transgenic mice, in which DC can be transiently ablated in vivo. We show a critical role for DC in initiation of the CD4(+) T cell response to the mycobacterial Ag early secretory Ag of tuberculosis 6. The delay in initiating the Ag-specilic T cell response led to impaired control of Mtb replication. Interestingly, DC were not required for the secondary CD4(+) T cell response following Mtb infection in peptide-vaccinated mice. Thus, this study shows that DC are essential for the initiation of the adaptive T cell response to the human pathogen Mtb.
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