期刊
ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE
卷 159, 期 9, 页码 876-881出版社
AMER MEDICAL ASSOC
DOI: 10.1001/archpedi.159.9.876
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资金
- NHLBI NIH HHS [HL69413, R01 HL069413-08, R01 HL069413, K24 HL074864, K24 HL074864-05] Funding Source: Medline
Objective: To describe families with multiple members affected with Kawasaki syndrome (KS) to increase awareness of the familial occurrence of KS among practitioners who care for these patients. Design: Retrospective review of medical records at 2 medical centers and data collection from remote KS families who contacted the KS Research Program at the University of California, San Diego. Results: Eighteen families with multiple affected members were identified. There were 9 families with 2 affected siblings. In San Diego, 3 (0.7%) of 424 KS families had sibling cases. Nine families were identified with KS in 2 generations or in multiple affected members, yielding a total of 24 KS-affected children. No clear pattern of inheritance could be deduced from these pedigrees, and it is likely that multiple polymorphic alleles influence KS susceptibility. Conclusion: Physicians should counsel affected families and make them aware of the potential increased risk of KS among family members.
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