Lehualides A-D, metabolites from a Hawaiian sponge of the genus Plakortis

A collection of an undescribed marine sponge of the genus Plakortis yielded four new polyketide-derived metabolites, lehualides A-D (1 -4). The structures of compounds 1 -4 were elucidated by interpretation Of spectral data. Compound 2 demonstrated cytotoxicity against an ovarian cancer cell line, while compound 4 was active against both ovarian cancer and leukemia cell lines.