期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 15, 期 17, 页码 3849-3852出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2005.05.120
关键词
apoptosis; inhibitor of eIF2 alpha dephosphorylation; synthesis
资金
- NIA NIH HHS [R37-AG012859] Funding Source: Medline
The synthesis and structure-activity relationships (SAR) of salubrinal, a small molecule that protects cells from apoptosis induced by endoplasmic reticulum (ER) stress, are described. It is revealed that the trichloromethyl group greatly contributes to the activity. Based on the SAR results, salubrinal was converted into a biotinylated derivative which retains activity and can be used as a biological tool for target identification. (c) 2005 Elsevier Ltd. All rights reserved.
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