期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 15, 期 17, 页码 3881-3885出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2005.05.131
关键词
quinazoline; Cdk
The inhibition of cyclin-dependent kinase 4 (Cdk4) causes cell cycle arrest and restores a checkpoint that is absent in the majority of tumor cells. Compounds that inhibit Cdk4 selectively are targeted for treating cancer. Appropriate substitution of 2-aminoquinazolines is demonstrated to produce high levels of selectivity for Cdk4 versus closely related serine-threonine kinases. (c) 2005 Elsevier Ltd. All rights reserved.
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