期刊
SYNLETT
卷 -, 期 14, 页码 2233-2235出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2005-872234
关键词
zinc; palladium; catalysis; cross-coupling; (+)-biotin
A phosphine-free catalytic system involving inexpensive Pd(OAc)(2) in conjunction with Zn dust and ZnBr2 was unexpectedly found to effect the Fukuyama coupling reaction of thiolactone 2 with zinc reagent 3 to provide vinyl sulfide 6, a key intermediate for (+)-biotin (1), in high yield with a very tiny amount of Pd (up to 0.01 mol%, TON = 6800).
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