期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 280, 期 35, 页码 31003-31010出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M504768200
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资金
- NCI NIH HHS [R01CA89614-O1A1] Funding Source: Medline
- NHLBI NIH HHS [P01 HL45100] Funding Source: Medline
Rho GTPases regulate multiple cellular processes including actin cytoskeletal rearrangements, transcriptional regulation, and oxidant production. The studies described herein demonstrate that small molecule redox agents, in addition to protein regulatory factors, can regulate the activity of redox- active Rho GTPases. A novel ( GXXXXGK( S/ T) C) motif, conserved in a number of Rho GTPases, appears critical for redox- mediated guanine nucleotide dissociation in vitro. A detailed molecular mechanism for redox regulation of GXXXXGK( S/ T) C motif- containing Rho GTPases is proposed.
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