期刊
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
卷 577, 期 1-2, 页码 179-194出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mrfmmm.2005.04.004
关键词
biology of ageing; NER-associated disease; transcription-coupled repair
资金
- NIA NIH HHS [1P01 AG17242-02] Funding Source: Medline
- NIEHS NIH HHS [1U01 ES011044] Funding Source: Medline
During the past decades, several cellular pathways have been discovered to be connected with the ageing process. These pathways, which either suppress or enhance the ageing process, include regulation of the insulin/growth hormone axis, pathways involved with caloric restriction, ROS metabolism and DNA repair. In this review, we will provide a comprehensive overview of cancer and/or accelerated ageing pathologies associated with defects in the multi-step nucleotide excision repair pathway. Moreover, we will discuss evidence suggesting that there is a causative link between transcription-coupled repair and ageing. Published by Elsevier B.V.
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