期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 519, 期 1-2, 页码 114-117出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejphar.2005.07.002
关键词
schizophrenia; NMDA receptor; phencyclidine; cognition; clozapine; haloperidol
This study was undertaken to examine the effects of subsequent administration of antipsychotic drugs (clozapine and haloperidol) on cognitive deficits in mice after repeated administration of phencyclidine (PCP). In the novel object recognition test, repeated administration of PCP (10 mg/kg) significantly decreased exploratory preference in the retention test session but not in the training test session. PCP-induced deficits were significantly improved by subsequent subchronic (2 weeks) administration of clozapine (5 mg/kg), but not haloperidol (0.1 mg/kg). These findings suggest that PCP-induced cognitive deficits using the novel object recognition test may be a potential animal model of atypical antipsychotic activity. (c) 2005 Elsevier B.V. All rights reserved.
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