期刊
TETRAHEDRON
卷 61, 期 36, 页码 8669-8676出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2005.06.113
关键词
aldol reactions; amino acids; asymmetric catalysis; organocatalysts; 4-substituted proline
A series of 4-substituted prolines were prepared and evaluated as organocatalysts for asymmetric aldol reactions. Using (2S,4R)4-camphorsulfonyloxy-proline, the aldol products were obtained in much higher enantiomeric excess in comparison to that observed using proline itself. In addition, the improved solubility of these new catalysts in organic solvents permits their use in lower sub-stoichiometric amounts compared to proline. (c) 2005 Elsevier Ltd. All rights reserved.
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