期刊
BRITISH JOURNAL OF CANCER
卷 93, 期 5, 页码 571-574出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6602722
关键词
Hodgkin's lymphoma; season of diagnosis; relative risk of death; vitamin D
类别
Experimental studies show that vitamin D derivatives are potent anticarcinogenic factors. Epidemiological observations support this, and vitamin D sufficiency has been hypothesised to be an important risk-reducing factor in several forms of cancer. Vitamin D level exhibits seasonal variations. In the present work, we have investigated the effect of the season of diagnosis on the risk of death among Hodgkin's lymphoma patients diagnosed in Norway between 1964 and 2000. Risk estimates were calculated as relative risk (RR), with 95% confidence intervals ( 95% CI), using Cox regression model. Epidemiological data for this period indicate that season of diagnosis is a strong prognostic factor for Hodgkin's lymphoma, with approximate to 20% lower case fatality for patients diagnosed during autumn vs winter diagnosis ( RR = 0.783, 95% CI, - 0.62 to 0.99; P = 0.041). Notably, the improved autumnal survival rate was higher than 60% ( RR = 0.364, 95% CI, - 0.15 to 0.87; P = 0.025) for patients younger than 30 years. This finding may be related to higher endogenous levels of vitamin D in autumn, with a favourable influence on the conventional therapy.
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