期刊
FEBS LETTERS
卷 579, 期 22, 页码 5089-5094出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2005.07.097
关键词
4.1 ezrin radixin moesin
资金
- MRC [G0000221] Funding Source: UKRI
- Medical Research Council [G0000221] Funding Source: Medline
- Multiple Sclerosis Society [669] Funding Source: Medline
- Medical Research Council [G0000221] Funding Source: researchfish
The 4.1 superfamily of proteins contain a 4.1 ezrin radixin moesin (FERM) domain and are described as linking the cytoskeleton with the plasma membrane. Here, we describe a new FERM domain-containing protein called Willin. Willin has a recognizable FERM domain within its N-terminus and is capable of binding phospholipids. Its intra-cellular distribution can be cytoplasmic or at the plasma membrane where it can co-localize with actin. However, the plasma membrane location of Willin is not influenced by cytochalasin D induced actin disruption but it is induced by the addition of epidermal growth factor. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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