期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 102, 期 37, 页码 13325-13330出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0505592102
关键词
optical imaging of intrinsic signals; rat; tonotopy; cortical maps
资金
- NEI NIH HHS [R01 EY002874, EY 02874, R37 EY002874] Funding Source: Medline
- NIDCD NIH HHS [R01 DC002260, R01 DC002260-10] Funding Source: Medline
- NINDS NIH HHS [NS 16033, P01 NS016033] Funding Source: Medline
We provide an overall view of the functional tonotopic organization of the auditory cortex in the rat. We apply a recently developed technique for acquiring intrinsic signal optical maps, Fourier imaging, in the rat auditory cortex.,These highly detailed maps, derived in a several-minute-long recording procedure, delineate multiple auditory cortical areas and demonstrate their shapes, sizes, and tonotopic order. Beyond the primary auditory cortex, there are at least three distinct areas with fine-scale tonotopic organization, as well as at least one additional high-frequency field. The arrangement of all of these cortical areas is consistent across subjects. The accuracy of these optical maps was confirmed by microelectrode mapping in the same subjects. This imaging method allows fast mapping of the auditory cortex at high spatial resolution comparable to that provided by conventional microelectrode technique. Although spiking activity is largely responsible for the evoked intrinsic signals, certain features of the optical signal cannot be explained by spiking activity only, and should probably be attributed to other mechanisms: inducing metabolic activity, such as subthreshold membrane phenomena.
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