期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 102, 期 37, 页码 13301-13306出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0506034102
关键词
amygdala; hippocampus; long-term potentiation; GABA; picrotoxin
资金
- NIMH NIH HHS [MH62822] Funding Source: Medline
- NINDS NIH HHS [NS045625, R01 NS044185, R01 NS045625, NS44185] Funding Source: Medline
The pathology of schizophrenia is characterized by increased hippocampal activity at baseline and during auditory hallucinations. Animal-model studies in which the flow of activity to the hippocampus is increased through decreased amygdalar GABAergic inhibition have shown alterations of hippocampal circuitry similar to schizophrenia, but the functional importance of this phenomenon remains unclear. We provide evidence of decreased hippocampal feed-forward and tonic GABA-mediated inhibition in this animal model, complementing increased hippocampal activity seen in neuroimaging and postmortem studies. We demonstrate that GABA dysfunction increases long-term potentiation through activation of the cholinergic system, offering a new mechanism for pharmacological strategies of this disorder.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据