期刊
ORGANIC LETTERS
卷 7, 期 19, 页码 4117-4120出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol051396s
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资金
- NIGMS NIH HHS [GM-62924] Funding Source: Medline
Psymberin is a sponge-derived natural product that shows striking selectivity as a cytotoxic agent. Conformational mobility has precluded stereochemical assignment for the acyl fragment of this molecule (psymberic acid) by NMR. Herein we report stereoselective syntheses of all four stereoisomers of psymberic acid. A comparison of the acid-mediated cyclization products of these compounds to the product of psymberin's acidic methanolysis showed the stereochemical configuration of this fragment to be 4S, 5S.
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