期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 13, 期 18, 页码 5338-5345出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2005.06.047
关键词
4-aminoquinoline derivatives; quinolizidine derivatives; antimalarial agents; chloroquine; P. falciparum
A set of quinolizidinyl and quinolizidinylalkyl derivatives of 4-amino-7-chloroquinoline and of 9-amino-6-chloro 2-methoxyacridine were prepared and tested in vitro against CQ-sensitive (D-10) and CQ-resistant (W-2) strains of Plasmodium falciparum. All compounds but one exerted significant antimalarial activity. Some of the quinolizidine derivatives were from 5 to 10 times more active than chloroquine on the CQ-resistant strain. No toxicity against mammalian cells was observed. (c) 2005 Elsevier Ltd. All rights reserved.
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