期刊
SYNLETT
卷 -, 期 15, 页码 2293-2296出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2005-872654
关键词
aldehyde; amine; alpha-aminonitrile; silica sulfuric acid; one-pot synthesis
A simple and efficient method has been developed for the synthesis of alpha-aminonitriles by a one-Pot three-component condensation of aldehydes, amines, and trimethylsilyl cyanide in the presence of a catalytic amount of silica sulfuric acid at room temperature. The silica sulfuric acid is reusable and could be applied in subsequent reactions with comparable activity.
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