期刊
NEUROREPORT
卷 16, 期 14, 页码 1585-1589出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.wnr.0000181578.72894.b9
关键词
A-type potassium current; copper; hippocampal CAI neuron; patch clamp; rat
The effects of copper on voltage-gated A-type potassium currents were investigated in acutely dissociated rat hippocampal CAI neurons using the whole-cell patch-clamp technique. Extracellular application of various concentrations of copper (1-1000 mu M) reversibly reduced the amplitude of voltage-gated A-type potassium currents in a dose-dependent manner with a 50% inhibitory concentration value of 130 mu M. Copper (300 mu M) increased the V-1/2 of the activation curve and state-inactivation curve by 17.2 and 9.0 mV, respectively Thus, copper slowed down the activation and inactivation process of voltage-gated A-type potassium currents. This study indicated that copper reversibly inhibits the hippocampal CAI neuronal voltage-gated A-type potassium current in a dose-dependent and voltage-dependent manner, and such actions are likely involved in the regulation of the neuronal excitability and the pathophysiology of Wilson's disease.
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