Synthesis, antimicrobial activity, and 77Se NMR of some new pyrrole derivatives containing a diphenyl selenide moiety

A simple and mild synthesis for pyrrolyl and pyrrolo[2,3-d]pyrimidinyl diphenyl selenides is described based on the reaction of active methylene compounds with 4 '-nitro-4-acetylainitiodiphenyl selenide. The sensitivity of Se-77 NMR spectra allowed differentiating the rather similar pyrrole compounds. The synthesized compounds were screened for their antifungal and antibacterial activities.