期刊
INTERNATIONAL JOURNAL OF UROLOGY
卷 12, 期 10, 页码 886-891出版社
WILEY
DOI: 10.1111/j.1442-2042.2005.01145.x
关键词
antiandrogen; CAD (coronary arterial disease); CPA (cyproterone acetate); hormonal therapy; prostate cancer
Aim: To study the change of lipid metabolism by antiandrogen therapy in patients with prostate cancer. Materials and methods: We studied with a 2.5 years follow-up the changes in plasma cholesterols (C), triglycerides (TG), lipoproteins (LP), and apolipoproteins (Apo) B-100, A-I, and A-II proles in 24 patients of mean age 60 years with low risk prostate cancer (stage: T1cN(0)M(0), Gleason score: 2-5) during treatment with cyproterone acetate (CPA) without surgical management or radiation therapy. Results: Signicant decreases of HDL-C, Apo A-I and Apo A-II and an increase of triglyceride levels in VLDL were induced by CPA. After a period of 2.5 years on CPA treatment, four patients out of twenty-four were found to be affected by coronary heart disease. Conclusions: Ischaemic coronary arteriosclerosis with an incidence rate of 16.6% as caused by prolonged CPA therapy is mediated through changes in HDL cholesterol, Apo A-I and Apo A-II proles, other than the well-known hyperglyceridemic effect caused by estrogen.
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