期刊
BEHAVIORAL NEUROSCIENCE
卷 119, 期 5, 页码 1396-1402出版社
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/0735-7044.119.5.1396
关键词
learning; memory; consolidation; freezing; timing
资金
- NIMH NIH HHS [5F31MH066549] Funding Source: Medline
Placing a trace interval between a warning signal and an aversive shock makes consolidation of the memory for trace conditioning hippocampus dependent. To determine the trace at which memory consolidation requires the hippocampus, mice were trained with 0-s, 1-s, 3-s, or 20-s trace intervals and tested for freezing to context and tone. Posttraining dorsal hippocampus (DH) lesions decreased context conditioning regardless of trace interval. However, DH lesions attenuated only the 20-s trace tone freezing. Like eyeblink conditioning, the DH is necessary for trace fear conditioning only at long trace intervals, but the time scale for the effective interval in fear conditioning is about 40 times longer. Manipulations that alter trace fear conditioning with short trace intervals probably do not reflect altered DH function. Given this difference in time scale along with the use of posttraining DH lesions, hippocampus dependency of trace conditioning is not related to a bridging function or response timing.
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