Effective removal of albumin from serum

The protein constituents of serum can range from grams to picograms per liter, making it tech- Received: July 16, 2004 nically difficult to achieve in-depth proteomic analysis. Removal of highly abundant proteins, Revised: December 29, 2004 such as albumin, coupled to powerful protein separation methods is required for increased Accepted: January 5, 2005 14 sample load, thus facilitating detection and identification of low-abundant proteins. We report here a chemical-based extraction method for the effective and specific removal of albumin from serum.