期刊
NEUROIMAGE
卷 27, 期 4, 页码 947-959出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2005.05.052
关键词
hemodynamic contrasts; hemoglobin; diffuse optical tomography; diffuse optical imaging; near-infrared spectroscopy; deoxy-hemoglobin; total hemoglobin
资金
- NCRR NIH HHS [P41-RR14075] Funding Source: Medline
- NINDS NIH HHS [R29-NS38842, K25-NS44339] Funding Source: Medline
With the aim of evaluating the relative performance of hemodynamic contrasts for mapping brain activity, the spatio-temporal response of oxy-, deoxy-, and total-hemoglobin concentrations were imaged with diffuse optical tomography during electrical stimulation of the rat somatosensory cortex. For both 6-s and 30-s stimulus durations, total hemoglobin images provided smaller activation areas than oxy- or deoxy-hemoglobin images. In addition, analysis of regions of interest near the sagittal sinus vein show significantly greater contrast in both oxy- and deoxy-relative to total hemoglobin, suggesting that oximetric contrasts have larger draining vein contributions compared to total hemoglobin contrasts under the given stimulus conditions. These results indicate that total hemoglobin and cerebral blood volume may have advantages as hemodynamic mapping contrasts, particularly for large amplitude, longer duration stimulus paradigms. (C) 2005 Elsevier Inc. All rights reserved.
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