期刊
GENETICS
卷 171, 期 2, 页码 663-672出版社
GENETICS SOC AM
DOI: 10.1534/genetics.105.043026
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资金
- NICHD NIH HHS [R01 HD041451, R01 HD4145:01] Funding Source: Medline
In female mammalian cells, the inactive X chromosome is replicated late in S phase while the active X chromosome is replicated earlier. The replication times of the X chromosomes reflect a general trend in which late replication is associated with gene repression and earlier replication with transcriptional competence. The X-linked Xist gene is expressed exclusively from the inactive X chromosome where it is involved in the initiation and maintenance of X-inactivation. In contrast, no biological activity has been assigned to the Xist locus of the active X chromosome where the Xist gene is transcriptionally silenced. Here, we Provide evidence that the element(s) at the nontranscribed Xist locus of the active X chromosome controls chromosomal replication timing in cis.
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