期刊
EPILEPSY RESEARCH
卷 67, 期 1-2, 页码 81-87出版社
ELSEVIER
DOI: 10.1016/j.eplepsyres.2005.08.009
关键词
seizure; 6 Hz; 2-deoxyglucose; antiepileptic drug; lacosamide; brain metabolism; cerebral cortex; hippocampus
Brain metabolic activation after 6 Hz electrical stimulation (32 mA, 3 s stimulus duration) was assessed by autoradiographic analysis of C-14-2-deoxyglucose (2-DG) uptake. In addition, effects of the new antiepileptic drug lacosamide were examined on the stimulation-induced metabolic activation. The 6 Hz stimulation via corneal electrodes induced a robust increase 2-DG uptake in cerebral cortical regions, lateral amygdala, and the caudate-putamen. Many other brain regions were not affected by the stimulation, including the hippocampal formation, medial nuclei of the amygdala, thalamus, and hypothalamus. Lacosamide (20 mg/kg) injected i.p. 30 min before application of electrical stimulation antagonized completely the seizure-induced brain metabolic activation but did not affect basal 2-DG uptake. The data provide evidence that lacosamide antagonizes the neural activation induced by an electrical seizure stimulus, without suppressing normal brain metabolic activity. (c) 2005 Elsevier B.V. All rights reserved.
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