期刊
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
卷 30, 期 4, 页码 269-273出版社
MEDECINE ET HYGIENE
DOI: 10.1007/BF03190631
关键词
astragaloside IV (AGS-IV); pharmacokinetics; rats; LC/MS/MS
Pharmacokinetics of Astragaloside IV (AGS-IV) in rats was studied by high performance liquid chromatography coupled with tandem mass spectrometry. The concentration in plasma was determined after iv administration of 1, 2, 4mg/kg and po administration of 20mg/kg of AGS-IV. The AUC were linearly correlated to doses. Recoveries of AGS-IV in bile, urine and feces were also analyzed following iv dose of 2 mg/kg. Cumulative recovery of AGS-IV in bile reached 30.8% in 24h. Cumulative recovery of AGS-IV in urine and feces was 52.14%, which indicates that about 50% of AGS-IV was metabolized in vivo. The bioavailability of AGS-IV after po administration was found to be 3.66%. These findings provide useful information for the research and development of AGS-IV and other potential agents.
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