期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 167, 期 1-2, 页码 13-22出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2005.06.013
关键词
IL-1; IL-6; TNF-alpha; IL-10; work-related musculoskeletal disorder; cumulative trauma disorder; median nerve
资金
- NIAMS NIH HHS [R03 AR046426-02, R03 AR046426-01] Funding Source: Medline
We examined cytokines in rat median nerves following performance of a high repetition reaching and grasping task at a rate of 8 reaches/min for Up to 8 weeks. IL-1 alpha, IL-1 beta, TNF-alpha, IL-6 and IL-10 were analyzed by immunohistochemistry. Double-labeling immunohistochemistry for ED1, a marker of phagocytic macrophages, was also performed. We found increased immunoexpression of IL-6 by week 3, increases in all 5 cytokines by week 5. This response was transient as all cytokines returned to control levels by 8 weeks of performance of a high repetition negligible force task. Cytokine sources included Schwann cells, fibroblasts and phagocytic macrophages (ED1-immunopositive). These findings suggest that cytokines are involved in the pathophysiology of repetitive motion injuries in peripheral nerves. (C) 2005 Elsevier B.V All rights reserved.
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