期刊
PEPTIDES
卷 26, 期 10, 页码 1800-1813出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2004.11.033
关键词
obesity; melanocortin; POMC; AGRP; thermogenesis; sympathetic nervous system; BAT; UCP; thyroid; central circuits; diet-induced thermogenesis; pathogenic stimuli
资金
- NIDDK NIH HHS [NIDDK57838, NIDDK 62179] Funding Source: Medline
Adaptive thermogenesis represents one of the important homeostatic mechanisms by which the body maintains appropriate levels of stored energy and its core temperature. Dysregulation of adaptive thermogenesis promotes obesity. The central melanocortin system, in particular the melanocortin 4 receptor (MC4R) signaling pathway, influences the regulation of every aspect of energy balance, including thermogenesis, and plays a critical role in energy homeostasis in both rodent and man. This review will outline our current understanding of adaptive thermogenesis, focusing on the role of the central melanocortin pathway in the regulation of thermogenesis. (c) 2005 Elsevier Inc. All rights reserved.
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