期刊
JOURNAL OF CELL SCIENCE
卷 118, 期 19, 页码 4327-4332出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.02619
关键词
programmed cell death; bacterial toxin-antitoxins; stressful conditions
类别
mazEF is a toxin-antitoxin module located on the Escherichia coli chromosome and that of some other bacteria, including pathogens. mazF specifies for a stable toxin, MazF, and mazE specifies for a labile antitoxin, MazE, that antagonizes MazF. MazF is a sequence-specific mRNA endoribonuclease that initiates a programmed cell death pathway in response to various stresses. The mazEF-mediated death pathway can act as a defense mechanism that prevents the spread of bacterial phage infection, allowing bacterial populations to behave like multicellular organisms.
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