期刊
NANO LETTERS
卷 5, 期 10, 页码 1905-1909出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl051199m
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- NHGRI NIH HHS [R01 HG003703, R01 HG003703-03, R21 HG003290-02, R21 HG003290] Funding Source: Medline
Voltage biased solid-state nanopores are used to detect and characterize individual single stranded DNA molecules of fixed micrometer length by operating a nanopore detector at pH values greater than similar to 11.6. The distribution of observed molecular event durations and blockade currents shows that a significant fraction of the events obey a rule of constant event charge deficit (ecd) indicating that they correspond to molecules translocating through the nanopore in a distribution of folded and unfolded configurations. A surprisingly large component is unfolded. The result is an important milestone in developing solid-state nanopores for single molecule sequencing applications.
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