期刊
NATURE NEUROSCIENCE
卷 8, 期 10, 页码 1298-1300出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn1543
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In this study, we assess the impact of normal aging on top-down modulation, a cognitive control mechanism that supports both attention and memory by the suppression and enhancement of sensory processing in accordance with task goals. Using fMRI ( functional magnetic resonance imaging), we show that healthy older adults demonstrated a prominent deficit in the suppression of cortical activity associated with task-irrelevant representations, whereas enhancement of task-relevant activity was preserved. Moreover, this suppression-specific attention deficit correlated with impaired working memory performance.
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