期刊
GENES & DEVELOPMENT
卷 19, 期 19, 页码 2289-2294出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1343705
关键词
X-chromosome dosage compensations; MSL complex
资金
- NIGMS NIH HHS [GM67825, K25 GM067825, GM45744, R01 GM045744, R37 GM045744] Funding Source: Medline
A long-standing model postulates that X-chromosome dosage compensation in Drosophila occurs by twofold up-regulation of the single male X, but previous data cannot exclude an alternative model, in which male antosomes are down-regulated to balance gene expression. To distinguish between the two models, we used RNA interference to deplete Male-Specific Lethal (MSL) complexes from male-like tissue culture cells. We found that expression of many genes from the X chromosome decreased, while expression from the autosomes was largely unchanged. We conclude that the primary role of the MSL complex is to up-regulate the male X chromosome.
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