期刊
CIRCULATION JOURNAL
卷 69, 期 10, 页码 1180-1185出版社
JAPANESE CIRCULATION SOC
DOI: 10.1253/circj.69.1180
关键词
acute myocardial infarction; coronary intervention; matrix metalloproteinase
Background Although the elevation of circulating plasma matrix metalloproteinase (MMP)-9 levels in patients with acute myocardial infarction (AMI) has been documented, the origin of MMP-9 remains unclear. Methods and Results Plasma MMP-9 levels in both the peripheral circulation and coronary arteries were measured in patients with AMI (n=23) and with stable angina pectoris (SAP, n=10) during percutaneous coronary intervention (PCI) with a distal protection device. Blood samples were collected from the femoral artery (FA) and the coronary artery before (Initial) and after (Second) dilation of the culprit lesion. Coronary sinus blood samples were obtained immediately after PCI (n=7). Coronary artery plaque fragments were aspirated in patients with AMI (n=20) and compared with those from patients with SAP who underwent directional atherectomy (n=10). MMP-9 levels in Initial and Second were significantly higher in patients with AMI than in patients with SAP (p < 0.01). In AMI patients MMP-9 levels were significantly higher in Initial than in the FA (p < 0.05), and were further increased in Second (p < 0.0001), whereas those in the coronary sinus were similar to the FA. Immunohistochemistry revealed augmented MMP-9 expression in the coronary artery plaque fragments from AMI patients. Conclusions MMP-9 is mainly released into the coronary circulation from the coronary artery plaque inpatients with AMI.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据