期刊
EUROPEAN HEART JOURNAL
卷 26, 期 19, 页码 1945-1955出版社
OXFORD UNIV PRESS
DOI: 10.1093/eurheartj/ehi333
关键词
nitric oxide; atherosclerosis; nitric oxide donor
Well-known risk factors for atherosclerosis include hypercholesterolaemia, hypertension, diabetes, and smoking. These conditions are associated with endothelial dysfunction, which itself is associated with reduced endothelial generation of nitric oxide (NO). This is an overview of the implications of NO generation in atherosclerosis and of the potential therapeutic benefit of drugs which donate NO, such as organic nitrates, nicorandil, and sydnonimines, or those which increase the availability of endogenous NO, such as statins, angiotensin-converting enzyme inhibitors, L-arginine, and tetrahydrobiopterin.
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