期刊
ANTIVIRAL RESEARCH
卷 101, 期 -, 页码 57-61出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.antiviral.2013.10.014
关键词
Cytomegalovirus; Multidrug resistance; Artesunate; Transplantation
Cytomegalovirus (CMV) strains resistant to ganciclovir, cidofovir and/or foscarnet were genotypically and phenotypically characterised in two haematopoietic stem cell transplant recipients and three solid-organ transplant recipients with CMV disease. The anti-malaria drug artesunate led to a favourable virological and clinical response in three cases with mild CMV diseases (fever and neutropaenia) but was ineffective in two fatal CMV diseases with lung involvement in spite of a decrease in the CMV DNA load in blood and bronchoalveolar fluid. (C) 2013 Elsevier B.V. All rights reserved.
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