期刊
ANTIVIRAL RESEARCH
卷 100, 期 1, 页码 246-254出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.antiviral.2013.08.014
关键词
Coronavirus; Spike protein; Severe acute respiratory syndrome; Middle East respiratory syndrome; Virus evolution
资金
- NIH [R01AI089728]
Receptor recognition is a major determinant of the host range, cross-species infections, and pathogenesis of the severe acute respiratory syndrome coronavirus (SARS-CoV). A defined receptor-binding domain (RBD) in the SARS-CoV spike protein specifically recognizes its host receptor, angiotensin-converting enzyme 2 (ACE2). This article reviews the latest knowledge about how RBDs from different SARS-CoV strains interact with ACE2 from several animal species. Detailed research on these RBD/ACE2 interactions has established important principles on host receptor adaptations, cross-species infections, and future evolution of SARS-CoV. These principles may apply to other emerging animal viruses, including the recently emerged Middle East respiratory syndrome coronavirus (MERS-CoV). This paper forms part of a series of invited articles in Antiviral Research on From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses. (C) 2013 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据