期刊
APPLIED RADIATION AND ISOTOPES
卷 63, 期 4, 页码 423-431出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.apradiso.2005.05.043
关键词
thermoresponsive; polymer; poly(N-isopropyl acrylamide); DTPA; tyrosinamide; local radiotherapy; yttrium-90; iodine-125
We describe a novel thermoresponsive polymeric drug delivery system based on poly(N-isopropylacrylamide) with isotopically labellable end groups [L-tyrosinamide or diethylenetriaminepentaacetic acid (DTPA)] designed for local radiotherapy. The polymers are readily soluble in isotonic aqueous sodium chloride at room temperature and the phase separation is complete at body temperature as proved by DSC measurements. Sufficent binding capacity for radionuclides and chemical stability are demonstrated on I-125 and Y-90-labelled polymers. (c) 2005 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据