期刊
APPLIED RADIATION AND ISOTOPES
卷 63, 期 4, 页码 443-456出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.apradiso.2005.03.014
关键词
polymer gel dosimetry; tetrakis (hydroxymethyl) phosphonium chloride; normoxic polymer gels; MAGAT
In this study, the response to ionsing radiation of the normoxic polymer gel dosimeter comprising tetrakis (hydroxymethyl) phosphonium chloride (THPC) with methacrylic acid (MAA) and gelatin, named MAGAT, has been investigated. Using magnetic resonance imaging (MRI), the R2-dose response or change in R2 (Delta R2) is evaluated for different concentrations of the component chemicals: THPC, MAA, gelatin and hydroquinone (HQ). The formulation for which the MAGAT polymer gel dosimeter had a maximum response was determined, and the spatial and temporal stability for this formulation analyzed. It was found that the formulation that provided the greatest change in R2 was 10 mM THPC, 0-0.05 mM HQ, 6-7% gelatin and 4-6% MAA (evaluated one day post-irradiation). MAGAT polymer gel dosimeters comprising 10 mM THPC, 0.05 mM HQ, 6-9% MAA and 4-6% gelatin have shown potential for use in radiation therapy dosimetry. (c) 2005 Elsevier Ltd. All rights reserved.
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