期刊
ANTIVIRAL RESEARCH
卷 93, 期 2, 页码 297-300出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.antiviral.2011.12.009
关键词
Chronic hepatitis B; Interferon-alpha therapy; Single nucleotide polymorphism; Interleukin 28B gene; Sustained virologic response
资金
- Foundation for Young Scientists of Peking Union Medical College [2010001]
- National Basic Research Program of China (973 Program) [2007CB512806]
- National High Technology Research and Development Program of China (863 Program) [2006AA02A4100]
- Science Fund for Creative Research Groups [31021091]
In 2009, three independent genome-wide association studies reported that genetic variation in the interleukin 28B gene to be associated with the response to interferon-alpha/ribavirin therapy in hepatitis C virus genotype 1 infected patients. We carried out the present study to assess whether such polymorphisms also affect the therapy effect of another interferon-alpha responsive illness as chronic hepatitis B. Five hundred and twelve interferon-alpha treatment-naive HBeAg seropositive chronic hepatitis B patients were enrolled in the present retrospective nested case-control study. All patients received PEG-IFN-alpha-2a based treatment and were examined for the therapy efficacy. SNP rs8099917 was genotyped using the Mass-Array system (Sequenom). Interestingly, the frequency of G allele of rs8099917 was significantly higher in response group than in non response group (8.3% vs. 3.9%, p = 0.003, OR = 0.44, 95%CI = 0.25-0.79). The genotype distributions of this SNP also differed significantly between two groups (p = 0.003). Our study suggested that the G allele of rs8099917 was associated with higher rate of response in HBeAg seropositive chronic hepatitis B patients treated with interferon alpha. (C) 2011 Elsevier B.V. All rights reserved.
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