期刊
ANTIVIRAL RESEARCH
卷 89, 期 3, 页码 232-237出版社
ELSEVIER
DOI: 10.1016/j.antiviral.2011.01.006
关键词
Hepatitis B virus (HBV); Interferon-alpha; HBsAg seroconversion; Single nucleotide polymorphism (SNP); 2 ',5 '-Oligoadenylate synthetase(OAS); Haplotype
资金
- National Eleventh Five-year Science and Technology Major Projects, China [2008ZX10002-013, 2008ZX10002-004]
- National High Technology Research and Development Program of China (863Program) [2006AA02A410]
\ To evaluate the role of host single nucleotide polymorphisms (SNPs) of 2',5'-oligoadenylate synthetase (OAS) in predicting IFN response in patients with HBV infection, OAS gene and four SNPs were examined in 363 patients with chronic HBV infection (including 41 patients with HBsAg seroconversion) and 57 healthy controls. One SNP and three haplotypes were identified after adjustment for age, sex, HBV DNA. The frequency of OAS3T/C heterozygotes is 52.2% in responders (R) and 38.2% in non-responders (NR), with an odds ratio (OR) of 1.511 (P=0.018). For complete responders (CR) and NR, the OR reached 2.323(P=0.023). Haplotype analyses revealed significant association between three OAS haplotypes and response to IFN-alpha treatment. Genotype combination and interaction between gene-gene analyses disclosed that there was a positive interaction between OAS2/OAS3 and OAS3/OASL, and the rate of OR was 2.46 (likelihood test. P = 0.004) and 4.46 (likelihood test, P = 0.004), respectively. Our results suggest that OAS gene variations may play an important role in response to IFN-alpha and provide a novel strategy for the resolution of HBV infection. (C) 2011 Elsevier B.V. All rights reserved.
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