期刊
ANTIVIRAL RESEARCH
卷 90, 期 1, 页码 64-69出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.antiviral.2011.02.008
关键词
3a protein; Corona virus; Emodin; Voltage clamp; Ion channel; Virus release
The open-reading-frame 3a of SARS coronavirus (SARS-CoV) had been demonstrated previously to form a cation-selective channel that may become expressed in the infected cell and is then involved in virus release. Drugs that inhibit the ion channel formed by the 3a protein can be expected to inhibit virus release, and would be a source for the development of novel therapeutic agents. Here we demonstrate that emodin can inhibit the 3a ion channel of coronavirus SARS-CoV and HCoV-OC43 as well as virus release from HCoV-OC43 with a K(1/2) value of about 20 mu M. We suggest that viral ion channels, in general, may be a good target for the development of antiviral agents. (C) 2011 Elsevier B.V. All rights reserved.
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