期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 167, 期 1-2, 页码 143-149出版社
ELSEVIER
DOI: 10.1016/j.jneuroim.2005.06.019
关键词
multiple sclerosis; soluble platelet endothelial cell adhesion molecule-1 (sPECAM-1); soluble e-selectin (sE-selectin); soluble p-selectin (sP-selectin); plasma
Adhesion molecule mediated leukocyte migration into the central nervous system is considered to be a critical step in the pathogenesis of multiple sclerosis (MS). We measured plasma levels of the soluble adhesion molecules sPECAM-1, sP-selectin and sE-selectin in 166 MS patients and in 36 healthy blood donors with ELISA. sPECAM-1, sP-selectin and sE-selectin plasma concentrations showed a significant increase in the relapsing-remitting disease course of MS and were elevated during relapse. These findings indicate that sPECAM-1, sP-selectin and sE-selectin might be implemented as paraclinical markers of disease activity in MS with restriction to the clinical course of the disease. (C) 2005 Elsevier B.V. All rights reserved.
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