期刊
ANTIVIRAL RESEARCH
卷 87, 期 2, 页码 111-124出版社
ELSEVIER
DOI: 10.1016/j.antiviral.2009.07.007
关键词
Alphavirus; Genomics; Structure/function studies; Replicative enzymes; Antivirals; Evolution; Classification; Biogeography; VIZIER
资金
- VIZIER (Comparative Structural Genomics of Viral Enzymes Involved in Replication) [2004-511960]
- National Institute of Health [U54-AI057156, R01-AI071192, R01-AI069145]
- Medical Research Council [G0801208] Funding Source: researchfish
- Natural Environment Research Council [CEH010021] Funding Source: researchfish
- MRC [G0801208] Funding Source: UKRI
The alphaviruses were amongst the first arboviruses to be isolated, characterized and assigned a taxonomic status. They are globally very widespread, infecting a large variety of terrestrial animals, insects and even fish, and circulate both in the sylvatic and urban/peri-urban environment, causing considerable human morbidity and mortality. Nevertheless, despite their obvious importance as pathogens, there are currently no effective antiviral drugs with which to treat humans or animals infected by any of these viruses. The EU-supported project VIZIER (Comparative Structural Genomics of Viral Enzymes Involved in Replication, FP6 Project: 2004-511960) was instigated with an ultimate view of contributing to the development of antiviral therapies for RNA viruses, including the alphaviruses [Coutard, B., Gorbalenya, A.E., Snijder, E.J., Leontovich, A.M., Poupon, A., De Lamballerie, X., Charrel, R., Gould, E.A., Gunther, S., Norder, H., Klempa, B., Bourhy, H., Rohayemj, J., L'hermite, E., Nordlund, P., Stuart, D.I., Owens, R.J., Grimes, J.M., Tuckerm, PA., Bolognesi, M., Mattevi, A., Coll, M., Jones, TA., Aqvist, J., Unger, T., Hilgenfeld, R., Bricogne, G., Neyts, J., La Colla, P., Puerstinger, G., Gonzalez, J.P., Leroy, E., Cambillau, C., Romette, J.L., Canard, B., 2008. The VIZIER project: preparedness against pathogenic RNA viruses. Antiviral Res. 78, 37-46]. This review highlights some of the major features of alphaviruses that have been investigated during recent years. After describing their classification, epidemiology and evolutionary history and the expanding geographic distribution of Chikungunya virus, we review progress in understanding the structure and function of alphavirus replicative enzymes achieved under the VIZIER programme and the development of new disease control strategies. (C) 2009 Elsevier B.V. All rights reserved.
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