期刊
ANTIVIRAL RESEARCH
卷 88, 期 3, 页码 343-346出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.antiviral.2010.09.009
关键词
HCoV 229E; tetra-para-Sulfonato-calix[4]arene; 1,3-Bis(bithiazolyl)-tetra-para-sulfonato-calix[4]arene; Antiseptic; Virucidal
资金
- French Ministry of further Education and Research
- French National Scientific Research Center
Facing the lack in specific antiviral treatment, it is necessary to develop new means of prevention. In the case of the Coronaviridae this family is now recognized as including potent human pathogens causing upper and lower respiratory tract infections as well as nosocomial ones. Within the purpose of developing new antiseptics molecules, the antiseptic virucidal activity of two calix[4]arene derivatives, the terra-para-sulfonato-calix[4]arene (C[4]S) and the 1,3-bis(bithiazolyl)-tetra-para-sulfonato-calix[4]arene (C[4]S-BTZ) were evaluated toward the human coronavirus 229E (HCoV 229E). Comparing these results with some obtained previously with chlorhexidine and hexamidine, (i) these two calixarenes did not show any cytotoxicity contrary to chlorhexidine and hexamidine, (ii) C[4]S showed as did hexamidine, a very weak activity against HCoV 229E, and (iii) the C[4]S-BTZ showed a stronger activity than chlorhexidine, i.e. 2.7 and 1.4 log(10) reduction in viral titer after 5 min of contact with 10(-3) mol L-1 solutions of C[4]S-BTZ and chlorhexidine, respectively. Thus, the C[4]S-BTZ appeared as a promising virucidal (antiseptic) molecule. (C) 2010 Elsevier B.V. All rights reserved.
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