期刊
ANTIVIRAL RESEARCH
卷 85, 期 3, 页码 559-561出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.antiviral.2009.12.010
关键词
Novel influenza A (H1N1) virus; RNA interference; siRNAs; Conserved regions
资金
- Ministry of Science and Technology of China [2005CB522905]
In March and April 2009, an entirely novel influenza A (H1N1) virus (NIAV) emerged in Mexico and the USA. During the subsequent months, the virus rapidly spread all over the world by person-to-person transmission. In this report, RNA interference (RNAi) was used as an antiviral agent to inhibit NIAV replication in A549 cells. Ten small interfering RNAs (siRNAs) targeting extremely conserved regions among multiple NIAV genomes could effectively block the replication of NIAV strain A/Beijing/01/2009 (H1N1) in A549 cells. This study may be useful to confront the sudden emergence of NIAV infection. (C) 2010 Elsevier B.V. All rights reserved.
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