期刊
ANTIVIRAL RESEARCH
卷 84, 期 2, 页码 101-118出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.antiviral.2009.08.002
关键词
Vaccine; Rift Valley fever virus; Non-structural protein; Bunyavirus; Phlebovirus; Reverse genetics; cDNA clone; Infectious clone; Minigenome rescue; Virus-like particle; Attenuation
资金
- NIAID NIH HHS [U01 AI066327-04] Funding Source: Medline
The advent of reverse genetics technology has revolutionized the study of RNA viruses, making it possible to manipulate their genomes and evaluate the effects of these changes on their biology and pathogenesis. The fundamental insights gleaned from reverse genetics-based studies over the last several years provide a new momentum for the development of designed therapies for the control and prevention of these viral pathogens. This review summarizes the successes and stumbling blocks in the development of reverse genetics technologies for Rift Valley fever virus and their application to the further dissection of its pathogenesis and the design of new therapeutics and safe and effective vaccines. (C) 2009 Elsevier B.V. All rights reserved.
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