Dihydrotrichodimerol and tetra hydrotrichodimerol, two new bisorbicillinoids, from a marine-derived Penicillium terrestre

Two new bisorbicillinoids possessing an open-ended cage structure, dihydrotrichodirrierol (1) and tetrahydrotrichodimerol (2), were isolated from a rnarine-derived Penicillium terrestre. Their structures were established by spectroscopic methods. Their cytotoxic activities against P388 and A-549 cell lines were preliminarily evaluated by the MTT method.