期刊
MUSCLE & NERVE
卷 32, 期 4, 页码 431-442出版社
WILEY
DOI: 10.1002/mus.20341
关键词
amyotrophic lateral sclerosis (ALS); cramp-fasciculation; fasciculation; muscle pain; myalgia; quinine; spasm
Muscle cramps are a common problem characterized by a sudden, painful, involuntary contraction of muscle. These true cramps, which originate from peripheral nerves, may be distinguished from other muscle pain or spasm. Medical history, physical examination, and a limited laboratory screen help to determine the various causes of muscle cramps. Despite the benign nature of cramps, many patients find the symptom very uncomfortable. Treatment options are guided both by experience and by a limited number of therapeutic trials. Quinine sulfate is an effective medication, but the side-effect profile is worrisome, and other membrane-stabilizing drugs are probably just as effective. Patients will benefit from further studies to better define the pathophysiology of muscle cramps and to find more effective medications with fewer side-effects.
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